Multiscale Microscopy of Biomaterials & Biointerfaces

The success of bone interfacing implants is strongly correlated to their osseointegration, their bonding with bone. However, little is known about the nanoscale structural and chemical attachment at bone-implant interfaces. We are using a variety of electron tomography and atom probe tomography approaches to study the bone-implant interface.

 

Select Publications:

Biointerfaces

Biomaterials

We are developing suitable biomaterials and surfaces for bone applications in dentistry and orthopaedics. We are exploring production and surface modifications including 3D-printing, electrospinning, laser-modification, and the associated in vitro and in vivo characterization for new biomaterials.

 

Select Publications:

Biomineralization

Utilizing state-of-the art approaches, including transmission electron microscopy, focused ion beam microscopy, atom probe tomography, and synchrotron-based studies we are probing the hierarchical structure and chemistry behind some of nature’s finest work, mineralized tissues.

 

Select Publications:

The Grandfield Research Group accesses the advanced infrastructure in core-laboratories across McMaster University, including:

 

• Canadian Centre for Electron Microscopy (CCEM)
• Faculty of Health Sciences Electron Microscopy Facility

• Biointerfaces Institute

• McMaster CAF

Equipment & Infrastructure

Grandfield Research Group | Dr. Kathryn Grandfield | Associate Professor | Materials Science and Engineering School of Biomedical Engineering | McMaster University,  ABB C305 | 1280 Main St W, Hamilton ON Canada L8S 4L7

Research funded by:

Multiscale Microscopy of Biomaterials & Biointerfaces