2023

chemrxiv, preprint.

In-Situ Liquid Phase Transmission Electron Microscopy and Electron Diffraction Provides Mechanistic Insight into Electrochemical CO2 Reduction on Palladium/Palladium Hydride Catalysts.

Abdellah, A., Ismail, F., Siig, O., Yang, J., Andrei, C. DiCecco, L., Rakhsha, A., Salem, K., Grandfield, K., Bassim, N., Black, R., Kastlunger, G., Soleymani, L., Higgins, D.

bioRxiv, preprint.

Characterizing Mineral Ellipsoids in New Bone Formation at the Interface of Ti6Al4V Porous Implants.

Deering, J., Chen, J., Mahmoud, D., Tang, T., Lin, Y., Fang, Q., Wohl, G.R., Elbestawi, M., Grandfield, K.

bioRxiv, preprint.

Osseointegration of functionally-graded Ti6Al4V porous implants: Histology of the pore network.

Deering, J., Mahmoud, D., Rier, E., Lin, Y., do Nascimento Pereira, A.C., Titotto, S., Fang, Q., Wohl, G.R., Deng, F., Grandfield, K., Elbestawi, M.A., Chen, J.

2022

Biomacromolecules, 24 (1), 258–268.

Unraveling the Supramolecular Structure and Nanoscale Dislocations of Bacterial Cellulose Ribbons Using Correlative Super-Resolution Light and Electron Microscopy.

Babi, M., Williams, A., Reid, M., Grandfield, K., Bassim, N.D., Moran-Mirabal, J.M.

JBMR Plus, 6 (12), e10693.

Multimodal and Multiscale Characterization of the Bone-Bacteria Interface in a Case of Medication-Related Osteonecrosis of the Jaw.

Micheletti, C., DiCecco, L., Larsson Wexell, C., Binkley, D.M., Palmquist, A., Grandfield, K., Shah, F.A.

Biomaterials Advances, 141, 213122.

Fabrication of succinate-alginate xerogel films for in vitro coupling of osteogenesis and neovascularization.

Deering, J., Lin, D.S.Y., D'Elia, A., Zhang, B., Grandfield, K.

Microscopy and Microanalysis, 28 (S1), 1528-1530.

Visualizing Early HCoV-229E Viral Infection Events Using Correlative 2D Light and 3D Electron Microscopy Techniques.

Williams, A., Davola, M., Mossman, K., Grandfield, K., Phaneuf, M.W., Bassim, N.

Microscopy and Microanalysis, 28 (S1), 1818-1820.

Exploring Calcium Phosphate Biomineralization Systems Using In Situ Liquid Phase Electron Microscopy.

DiCecco, L.A., Gao, R., Athanasiadou, D., Chan, R.L., Carneiro, K.M.M., Kelly, D.F., Sone, E., Grandfield, K.

Journal of Visualized Experiments: Jove, 185.

Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice.

DiCecco, L.A., Berry, S., Jonaid, G.M., Solares, M.J., Kaylor, L., Gray, J.L., Bator, C.

Acta Biomaterialia, 148, 44-60.

Atom probe tomography for biomaterials and biomineralization.

Grandfield, K., Micheletti, C., Deering, J., Arcuri, G., Tang, T., Langelier, B.

Bone Reports, 16, 101430.

Impact of Leptin Receptor (LepR) Gene Deficiency and Type 2 Diabetes Mellitus on Endochondral and Intramembranous Ossification in a Rat Model.

Micheletti, C., Shah, F.A., Grandfield, K., Palmquist, A.

Biomaterials Advances, 134, 112688.

PTH 1-34-functionalized bioactive glass improves peri-implant bone repair in orchiectomized rats: Microscale and ultrastructural evaluation.

Silva Gomes-Ferreira, P.H., Micheletti, C., Frigerio, P.B., de Souza Batista, F.R., Monteiro, N.G., Bim-Júnior, O., Lisboa-Filho, P.N., Grandfield, K., Okamoto, R.

Acta Biomaterialia, 142, 1-13.

Bone Mineral Organization at the Mesoscale: A Review of Mineral Ellipsoids in Bone and at Bone Interfaces.

Micheletti, C., Hurley, A., Gourrier, A., Palmquist, A., Tang, T., Shah, F.A., Grandfield, K.

Micron, 153, 103192.

Ionic liquid treatment for efficient sample preparation of hydrated bone for scanning electron microscopy.

DiCecco, L.A., D’Elia, A., Quenneville, C., Soleymani, L., Grandfield, K.

2021

Materials Science and Engineering: C, 112688.

PTH 1-34-functionalized bioactive glass improves peri-implant bone repair in orchiectomized rats: Microscale and ultrastructural evaluation.

Gomes-Ferreira, P.H.S., Micheletti, C., Frigério, P.B., de Souza Batista, F.R., Monteiro, N.G., Bim-Júnior, O., Lisboa-Filho, P.N., Grandfield, K., Okamoto, R.

Journal of the Mechanical Behavior of Biomedical Materials, 124, 104850.

Resonance vibration interventions in the femur: Experimental-numerical modelling approaches.

Presas, C., Valentin, D., Deering, J., Kampschulte, M., Yu, B., Grandfield, K., Mele, E., Biehl, C., Krombach, G.A., Heiss, C., Bosbach, W.A.

Orthopaedic Proceedings 103 (SUPP_13), 29-29.

Bone microarchitecture in a pre-clinical rat model for Type 2 Diabetes.

Micheletti, C., Shah, F.A., Grandfield, K., Palmquist, A.

Journal of the Royal Society Interface, 18 (182), 20210181.

From tissue retrieval to electron tomography: nanoscale characterization of the interface between bone and bioactive glass.

Micheletti, C., Gomes-Ferreira, P.H.S., Casagrande, T., Lisboa-Filho, P.N.

Advanced Biology, 5 (9), 2100657.

Visualization of Collagen–Mineral Arrangement using Atom Probe Tomography.

Lee, B.E.J., Langelier, B., Grandfield, K.

Nano Letters, 21 (16), 6898-6906.

Three-dimensional insights into interfacial segregation at the atomic scale in a nanocrystalline glass-ceramic.

Fu, L., Williams, J., Micheletti, C., Lee, B.E.J., Xu, G., Huang, J., Engqvist, H., Xia, W, Grandfield, K.

ChemBioChem, 22 (15), 2488-2506.

Electron Microscopy Imaging Applications of Room Temperature Ionic Liquids in the Biological Field: A Review

DiCecco, L.A., D'Elia, A., Miller, C., Sask, K.N., Soleymani, L., Grandfield, K.

Microscopy and Microanalysis, 27 (S1), 566-569.

Correlative light and electron microscopy for the study of the structural arrangement of bacterial microcrystalline cellulose microfibrils.

Williams, A., Babi, M., Reid, M., Grandfield, K., Moran-Mirabal, J., Bassim, N.

Materials Science and Engineering: C, 125, 112070.

Implant resonance and the mechanostat theory: Applications of therapeutic ultrasound for porous metallic scaffolds.

Deering, J., Presas, A., Yu, B., Valentin, D., Heiss, C., Bosbach, W.A., Grandfield, K.

Biomaterials and Biosystems, 2, 100013.

Current interpretations on the in vivo response of bone to additively manufactured metallic porous scaffolds: A review

Deering, J., Grandfield, K.

Journal of the Mechanical Behavior of Biomedical Materials, 116, 104361

Selective Voronoi tessellation as a method to design anisotropic and biomimetic implants.

Deering, J., Dowling, K.I., DiCecco, L.A., McLean, G.D., Yu, B., Grandfield, K.

Nano Express, 2 (1), 010018.

Drug release from polymer-coated TiO2 nanotubes on additively manufactured Ti-6Al-4V bone implants: a feasibility study.

Micheletti, C., Suriano, R., Grandfield, K., Turri, S.

ChemBioChem, 22 (3), 571-576.

Simultaneous Visualization of Wet Cells and Nanostructured Biomaterials in SEM using Ionic Liquids.

Lee, B.E.J., DiCecco, L.A., Exir, H., Weck, A., Sask, K.N., Grandfield, K.

2020

Journal of Structural Biology, 212(2): 107615.

Ellipsoidal mesoscale mineralization pattern in human cortical bone revealed in 3D by plasma focused ion beam serial sectioning.

Binkley, D.M., Deering, J., Yuan, H., Gourrier, A., Grandfield, K.

Cement and Concrete Research, 136, 106179.

The impacts of in-situ carbonate seeding on the early hydration of tricalcium silicate.

Monkman, S., Lee, B.E.J., Grandfield, K., MacDonald, M., Raki, L.

Materials Letters 274(1): 128057.

Composite Dip Coating Improves Biocompatibility of Porous Metallic Scaffolds.

Deering, J., Clifford, A., D’Elia, A., Zhitomirsky, I., Grandfield, K.

bioRxiv, pre-print.

Visualization of Collagen–Mineral Arrangement using Atom Probe Tomography.

Lee, B.E.J., Langelier, B., Grandfield, K.

ACS Applied Polymer Materials, 2(8): 3390-3395.

Electrochemical Fabrication and Characterization of Pectin Hydrogel Composite Materials for Bone Tissue Repair.

Clifford, A., D’Elia, A., Deering, J., Grandfield, K., Zhitomirsky, I.

Osteoporosis International, 31, 1807-1815.

Teriparatide improves microarchitectural characteristics of peri-implant bone in orchiectomized rats.

Gomes-Ferreira, P.H.S., de Oliveira, D., Frigério, P.B., de Souza Batista, F.R., Grandfield, K., Okamoto, R.

Bone, 135, 115304.

A search for apatite in the gap zone of collagen using dark-field illumination.

Schwarcz, H.P., Binkley, D.M., Luo, L., Grandfield, K.

Journal of the Mechanical Behaviour of Biomedical Materials. In Press, 103726.

Response of Saos-2 osteoblastic-like cells to kilohertz-resonance excitation in porous metallic scaffolds.

Deering, J., Presas, A., Lee, B.E.J., Valentin, D., Yu, B., Heiss, C., Grandfield, K., Bosbach, W. A.

Nanotechnology, 31, 235101.

Ti–5Al–5Mo–5V–3Cr bone implants with dual-scale topography: a promising alternative to Ti–6Al–4V.

Micheletti, C., Lee, B.E.J., Deering, J., Binkley, D.M., Coulson, S., Hussanain, A., Zurob, H., Grandfield, K.

Colloids and Surfaces B: Biointerfaces, 188, 110763.

Electrophoretic deposition of polymethylmethacrylate and composites for biomedical applications.

D’Elia, A., Deering, J., Clifford, A., Lee, B.E.J., Grandfield, K., Zhitomirsky, I.

2019

Flexible Hierarchical Wraps Repel Drug Resistant Gram Negative and Positive Bacteria. ACS Nano.14,1,454-465.

Flexible Hierarchical Wraps Repel Drug Resistant Gram Negative and Positive Bacteria.

Imani, S., MacLachlan, R., Rachwalski, K., Chan, Y., Lee, B.E.J.,McInnes, M.,  Grandfield, K., Brown, E., Didar, T., Soleymani, L.

Advanced Biosystems, 3(10): 1900126.

A Bioprinted in vitro Model for Osteoblast to Osteocyte Transformation by Changing Mechanical Properties of the ECM.

Lee, B.E.J., Shahin-Shamsabadi, A., Wong, M., Raha, S., Selvaganapathy, P.R. Grandfield, K.

Colloids and Surfaces B: Biointerfaces, 182: 110386.

Niobium pentoxide and hydroxyapatite particle loaded electrospun polycaprolactone/gelatin membranes for bone tissue engineering.

Marins, N., Lee, B.E.J., Silva, R., Raghavan, A., Carreno, N., Grandfield, K.

Micron, 102706.

Identification of collagen fibrils in cross sections of bone by electron energy loss spectroscopy.

Lee, B.E.J., Luo, L., Grandfield, K., Andrei, C., Schwarcz, H.P.

Colloids and Surfaces B: Biointerfaces, 176: 115-121.

Biomimetic modification of poly-l-lysine and electrodeposition of nanocomposite coatings for orthopaedic applications.

Clifford, A., Lee, B.E.J., Grandfield, K., Zhitomirsky, I.

Acta biomaterialia, 87: 152-165.

Cross-linked cellulose nanocrystal aerogels as viable bone tissue scaffolds.

Osorio, D.A., Lee, B.E.J., Kwiecien, J.M., Wang, X., Shahid, I., Hurley, A.L., Cranston, E.D., Grandfield, K.

Nanotechnology, 30 (21): 215101

Fabrication of polycaprolactone electrospun nanofibers doped with silver nanoparticles formed by air plasma treatment.

Binkley, D.M., Lee, B.E.J., Saem, S., Moran-Mirabal, J.M., Grandfield, K.

Nanoscale, 11(10):4345-4354.

Nondestructive, longitudinal measurement of collagen scaffold degradation using computed tomography and gold nanoparticles.

Finamore, T.A., Curtis, T.E., Tedesco, J.V., Grandfield, K., Roeder, R.K.

Microscopy Today, 27 (2): 12-19.

Correlative Spectromicroscopy and Tomography for Biomedical Applications Involving Electron, Ion, and Soft X-ray Microscopies.

Hitchcock, A.P., Wang, X., Grandfield, K., Everett, J., Collingwood, J.F., Telling, N.D.

2018

Communications Chemistry, 1 (80): 10.1038/s42004-018-008.

Biomineralization of calcium phosphate revealed by in situ liquid-phase electron microscopy.

Wang, X., Yang, J., Andrei, C.M., Soleymani, L.,  Grandfield, K.

Calcified Tissue International, 103 (6): 606-616.

Ultrastructure of Bone: Hierarchical Features from Nanometer to Micrometer Scale Revealed in Focused Ion Beam Sections in the TEM.

Grandfield, K., Vuong, V., Schwarcz, H.P.

Advanced Materials Interfaces, 1800262.

Biomineralization at Titanium Revealed by Correlative 4D Tomographic and Spectroscopic Methods.

Wang, X. Y., Langelier, B., Shah, F.A.,  Korinek, A., Bugnet, M., Hitchcock, A.P., Palmquist, A., Grandfield, K.

Journal of Materials Science. 53(13): 9842-9860.

Morphology of Cross-linked Cellulose Nanocrystal Aerogels: Cryo-templating vs. Pressurized Gas Expansion Processing.

Osorio, D.A., Seifried, B., Moquin, P., Grandfield, K., Cranston, E.D.

Applied Surface Science, 441: 1034-1042.

Characterization and Evaluation of Femtosecond Laser-Induced Sub-micron Periodic Structures Generated on Titanium to Improve Osseointegration of Implants.

Lee, B.E.J., Exir, H., Weck, A., Grandfield, K.

ACS Biomaterials Science & Engineering, 4(11): 3678-3690.

Advances in Multiscale Characterization of Bone and Biomaterials Interfaces.

Binkley, D.M., Grandfield, K.

2017

International Journal of Dentistry, ID 5920714.

Osseointegration of a 3D printed stemmed titanium dental implant: A pilot study.

Tedesco, J., Lee, B.E.J., Lin, A. Y-W., Binkley, D.M., Delaney, K.H., Kwiecien, J.M., Grandfield, K.

Nano Letters,17 (10), 6210-6216.

Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone.

Shah, F.A., Lee, B.E.J., Tedesco, J., Wexell, C.L., Persson, C., Thomsen, P., Grandfield, K., Palmquist, A.

Materials, 10(2), 173.

Influence of Substrate Heating and Nitrogen Flow on the Composition, Morphological and Mechanical Properties of SiNx Coatings Aimed for Joint Replacements.

Skjöldebrand, C., Schmidt, S., Vuong, V., Pettersson, M., Grandfield, K., Högberg, H., Engqvist, H., Persson, C.

Nature Scientific Reports, 7, 39958.

Atomic scale chemical tomography of human bone.

Langelier, B., Wang, X., Grandfield, K.

2016

ACS Biomaterials Science & Engineering, 3(1), 49-55.

3D characterization of human nano-osseointegration by on-axis electron tomography without the missing wedge.

Wang, X., Shah, F.A., Palmquist, A., Grandfield, K.

Surface and Coatings Technology, 296, 149-156.

Dual-topography electrical discharge machining of titanium to improve biocompatibility.

Lee, B.E.J., Ho, S., Mestres, G., Karlsson Ott, M., Koshy, P., Grandfield, K.

CrystEngComm, 18, 1064-1069.

Synthesis of calcium phosphate crystals with thin nacreous structure.

Chen, S., Grandfield, K., Shun, Y., Engqvist, H., Xia, W.

Archives of Oral Biology, 63, 82-92.

Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues.

Kurylo, M.P., Grandfield, K., Aloni, S., Altoe, V., Marshall, G.W., Young, M., Ho, SP.