Multiscale Microscopy of Biomaterials & Biointerfaces

Dr. Kathryn Grandfield is an Associate Professor and Tier II Canada Research Chair in Microscopy of Biomaterials and Biointerfaces in the Department of Materials Science & Engineering and School of Biomedical Engineering at McMaster University where her research interests include development of biomaterials and correlative multi-scale microscopies for biointerfaces and mineralized tissues. She is the recipient of the 2017 Petro Canada Young Innovator Award, a 2018 Early Researcher Award from the Ontario Ministry of Research Science and Innovation, and the 2019 McMaster Faculty of Engineering Teaching Excellence Award. She has served on the board of the Canadian Biomaterials Society and as inaugural Director of User Operations for the Canadian Centre for Electron Microscopy. She is currently President of the Microscopical Society of Canada.

 

Postdoc, Preventative and Restorative Dental Sciences, University of California, San Francisco (2013)

PhD, Engineering Sciences, Uppsala University, Sweden (2012)

M.A.Sc., Materials Science and Engineering, McMaster University, Canada (2010)

B.Eng., Materials Science and Engineering, McMaster University, Canada (2008)

Kathryn Grandfield

Adjunct Assistant Professor, Materials Science and Engineering

Research Associate, Grandfield Lab

 

Dr. Tang leads an independent research program within the Grandfield lab focused on multiscale structure-mechanics-function studies of mineralized tissues with advanced characterization approaches. Dr. Tang completed her Ph.D. under the supervision of Dr. Rizhi Wang and Dr. Peter Cripton (University of British Columbia) where she studied deformation and fracture mechanisms and structural fragility of human bone. Dr. Tang then conducted post-doctoral research in Germany (Max Planck Institute of Colloids and Interfaces) with Dr. Wolfgang Wagermaier and Dr. Peter Fratzl, where she investigated fundamental biomineralization mechanisms in a variety of biological tissues, such as tendon, bone, cartilage, and tesserae using 3D imaging techniques, including FIB-SEM.

 

Tengteng (Toni) Tang

PhD Candidate, MSE

Alessandra received both her B.Eng and M.Eng in Materials Science and Engineering from Politecnico di Torino, Italy, with exchanges in the US and Sweden. Her research, co-supervised by Prof. K Sask, focuses on correlative techniques for the characterization of proteins and cells at biomaterials interface.

Alessandra Merlo

PhD Candidate, MSE, NSERC Vanier Scholarship

Liza holds the NSERC Vanier Canadian Graduate Scholarship and completed an Honours B.Sc. in Mechanical Engineering with a Materials Specialization (UWindsor) and a M.A.Sc. in Engineering Materials (UWindsor). Her research focuses exploring the mechanisms behind biomineralization processes as well as using and developing advanced electron microscopy (EM) methods to characterize biological materials, with a focus on liquid-EM.

Liza-Anastazia DiCecco

PhD Candidate, MSE

Chiara received a B.Eng. in Mechanical and Materials Engineering (University of Brescia, Italy) and a double Master’s degree in Materials Science, Engineering and Nanotechnology (McMaster University and Politecnico di Milano, Italy). She is now pursuing a double Ph.D. degree in Materials Science and Engineering at McMaster University, and in Medical Science at the Sahlgrenska Academy (University of Gothenburg, Sweden), co-supervised by Prof. A Palmquist and Dr. F Shah. Her Ph.D. research focuses on the multimodal and multiscale (micro-to-nano) characterization of bone and bone interfaces in both healthy and compromised conditions (e.g., osteoporosis and diabetes).

Chiara Micheletti

Postdoctoral Fellow, MSE

Dr. Zhang completed her Ph.D. (2022) at Huazhong Agricultural University, China under the direction of Prof. Lijun Wang. Her scientific interests were focused on the crystallization and phase transformation of biological materials (especially calcium-based minerals), attempting to reveal the formation of biominerals (e.g. bone, teeth and pathological minerals). Her current research, co-supervised by Prof. Eli D. Sone (University of Toronto), focuses on understanding the molecular control of collagen biomineralization with advanced electron microscopy (EM), such as liquid-EM, and to apply these insights in bioinspired materials design.

Jing Zhang

Potdoctoral Fellow, MSE

Dr. Scott’s work focusses on imaging protein structure in vitro and in cells using light and electron microscopy techniques, in co-supervision with Prof. Kyla Sask. Dr. Scott characterized protein hydrogels with tunable mechanical properties under Prof. James Harden (University of Ottawa). He obtained his PhD while supervised by Prof. Sabrina Leslie (McGill University), where he used a novel single-molecule imaging technique to characterize DNA structural dynamics and their related molecular interactions. Next, he imaged DNA origami using super-resolution microscopy as a guest researcher at LMU with Prof. Philip Tinnefeld. As a postdoctoral fellow, he developed a novel means of dynamically and reversibly tuning polymer hydrogel mechanical properties with Prof. Christine Selhuber-Unkel in Germany (Kiel University), where he also built a light-sheet microscope to image neurons firing in living box jellyfish brains with Prof. Peer Wulff and Prof. Heinrich Terlau.

Shane Scott

PhD Candidate, BME and Cotutelle Université Grenoble Alpes

Lauren Anderson

PhD Candidate, BME, NSERC CGS D

Alyssa currently holds an NSERC CGS D  scholarship and completed an Honours BSc. in Biological Sciences with a specialization in Life Sciences and a minor in Chemistry from Ontario Tech University.  Her research, co-supervised by Prof. N Bassim, focuses on the imaging of biological and biomaterial nano-scale interactions and events using advanced 3D electron microscopy techniques.

Alyssa Williams

Undergraduate Students

 

 

Jacqueline Huo, Research Assistant, Engineering Physics and iBiomed Program

Justin Cusato, Thesis Student, Biomedical Discovery and Commercialization

Blanca Keohan, Thesis Student, Materials and iBiomed Program

Yushi (Steven) Wang, iBiomed

Alumni

Postdoctoral Fellows

 

Dr. Lourdes Couoh, 2017

Dr. Xiaoyue Wang, 2019

 

 

 

PhD Students Supervised

 

Xiaoyue Wang, 2017, MSE

Natália Hadler Marins, 2018, MSE Exchange

Bryan Lee, 2020, BME

Pedro Gomes Ferreira, 2020, FAPESP Visiting Exchange in MSE

Joe Deering, 2021, MSE

Jeromy Williams, MSE

 

 

 

MASc Students Supervised

 

Vicky Vuong, 2015, MSE

Emily-Rose Creighton, 2016, BME

Furqan Shah, 2016, Visiting Exchange in MSE

James Tedesco, 2017, MSE

Daniel Osorio, 2017, MSE

Chiara Micheletti, 2018, MSE

Dakota Binkley, 2019, MSE

Ivan Strakhov, 2019, BME

Undergraduate Students Supervised

 

Carolyn Willems, 2014, MSE, McMaster

Samantha Ho, 2014, MSE, McMaster

Pauline Bialas, 2014, Coop Student, INPG Grenoble

Kristoff Malejczuk, 2015, Coop Student, Waterloo

Alex Lin, 2015, Materials Engineering, Northwestern

Patricia Nguyen, 2015, Kinesiology, McMaster

Madeline Perrin, 2016, Coop Student, Materials Engineering, McGill

Christopher Schankula, 2017, Computer Sciences, McMaster

Dakota Binkley, 2017, Integrated Sciences, McMaster

Iflah Shahid, 2018, NSERC USRA, Honours Chemical Biology, McMaster

Arjun Raghavan, 2018, Dean's Excellence Undergraduate Award, iBiomed, McMaster

Ariana Hurley, 2018, iBiomed, McMaster

Asad Hussanain, 2018, NSERC USRA, Mechanical Engineering and Management, McMaster

Arjun Raghavan, 2019, iBiomed, McMaster

Griffin Mclean, 2019, iBiomed and Mechanical Engineering, McMaster

Kierdra Dowling, 2020, Materials Science and Engineering, McMaster

Jacky Winitsky, 2020, Integrated Biomedical Engineering & Health Sciences, McMaster

Ariana Hurley, 2020, Integrated Biomedical Engineering & Health Sciences, McMaster

Andrew D'Elia, 2020, Integrated Biomedical Engineering & Health Sciences, McMaster

Kamal Saad, 2021, Honours Life Science, McMaster

Ryan Lee Chan, 2021, MSE, McMaster

Anna Pereira, 2022, Exchange Student, Federal University ABC, Brazil

Anna Chen, 2022, iBiomed, McMaster

 

 

Samna Aziz, 2016, High School Coop Student

Grandfield Research Group, Iflah Shahid

Iflah Shahid

2018 Alumnus

Grandfield Research Group, Daniel Osorio

Daniel Osorio

2017 Alumnus

Grandfield Research Group, James Tedesco

James Tedesco

2017 Alumnus

Grandfield Research Group, Lourdes Couoh

Lourdes Couoh

2017 Alumnus

2019 Alumnus

Arjun Raghavan

2018 Alumnus

Asad Hussanain

2018 Alumnus

Natália Hadler Marins

Grandfield Research Group, Xiaoyue Wang

2019 Alumnus

Xiaoyue Wang

2019 Alumnus

Dakota Binkley

2020 Alumnus

Kierdra Dowling

2019 Alumnus

Ivan Strakhov

Griffin McLean

2019 Alumnus

2020 Alumnus

Andrew D'Elia

2020 Alumnus

Ariana Hurley

2020 Alumnus

Bryan Lee

2020 Alumnus

Jacky Winitsky

Kamal Saad

Ryan Lee Chan

Jeromy WIlliams

2021 Alumnus

Joe Deering

Anna Chen

Grandfield Research Group | Dr. Kathryn Grandfield | Associate Professor | Materials Science and Engineering School of Biomedical Engineering | McMaster University,  ABB C305 | 1280 Main St W, Hamilton ON Canada L8S 4L7

Research funded by:

Undergraduate Students

Multiscale Microscopy of Biomaterials & Biointerfaces