Multiscale Microscopy of Biomaterials

The success of bone interfacing implants is strongly correlated to their osseointegration, their bonding with bone. However, little is known about the nanoscale structural and chemical attachment at bone-implant interfaces. We are using a variety of electron tomography and atom probe tomography approaches to study the bone-implant interface.

 

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Biointerfaces

We are developing suitable biomaterials and surfaces for bone applications in dentistry and orthopaedics. We are exploring production and surface modifications including 3D-printing, electrospinning, laser-modification, and the associated in vitro and in vivo characterization for new biomaterials.

 

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Biomaterials

Biomineralization

Utilizing state-of-the art approaches, including transmission electron microscopy, focused ion beam microscopy, atom probe tomography, and synchrotron-based studies we are probing the hierarchical structure and chemistry behind some of nature’s finest work, mineralized tissues.

 

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The Grandfield Research Group accesses the advanced infrastructure in core-laboratories across McMaster University, including:

 

• McMaster CAF

Equipment & Infrastructure

Grandfield Research Group | Dr. Kathryn Grandfield | Assistant Professor | Materials Science and Engineering School of Biomedical Engineering | McMaster University, ETB rm 403 | 1280 Main St W, Hamilton ON Canada L8S 4L7

Research funded by:

Multiscale Microscopy of Biomaterials