On the Cover



Communications Chemistry, 1 (80): 10.1038/s42004-018-008.

Biomineralization of calcium phosphate revealed by in situ liquid-phase electron microscopy.

Wang, X., Yang, J., Andrei, C.M., Soleymani, L.,  Grandfield, K.



Calcified Tissue International, 103 (6): 606-616.

Ultrastructure of Bone: Hierarchical Features from Nanometer to Micrometer Scale Revealed in Focused Ion Beam Sections in the TEM.

Grandfield, K., Vuong, V., Schwarcz, H.P.



Advanced Materials Interfaces, 1800262.

Biomineralization at Titanium Revealed by Correlative 4D Tomographic and Spectroscopic Methods.

Wang, X. Y., Langelier, B., Shah, F.A.,  Korinek, A., Bugnet, M., Hitchcock, A.P., Palmquist, A., Grandfield, K.



Journal of Materials Science. 53(13): 9842-9860.

Morphology of Cross-linked Cellulose Nanocrystal Aerogels: Cryo-templating vs. Pressurized Gas Expansion Processing.

Osorio, D.A., Seifried, B., Moquin, P., Grandfield, K., Cranston, E.D.



Applied Surface Science, 441: 1034-1042.

Characterization and Evaluation of Femtosecond Laser-Induced Sub-micron Periodic Structures Generated on Titanium to Improve Osseointegration of Implants.

Lee, B.E.J., Exir, H., Weck, A., Grandfield, K.



ACS Biomaterials Science & Engineering, 4(11): 3678-3690.

Advances in Multiscale Characterization of Bone and Biomaterials Interfaces.

Binkley, D.M., Grandfield, K.






International Journal of Dentistry, ID 5920714.

Osseointegration of a 3D printed stemmed titanium dental implant: A pilot study.

Tedesco, J., Lee, B.E.J., Lin, A. Y-W., Binkley, D.M., Delaney, K.H., Kwiecien, J.M., Grandfield, K.



Nano Letters,17 (10), 6210-6216.

Micrometer-Sized Magnesium Whitlockite Crystals in Micropetrosis of Bisphosphonate-Exposed Human Alveolar Bone.

Shah, F.A., Lee, B.E.J., Tedesco, J., Wexell, C.L., Persson, C., Thomsen, P., Grandfield, K., Palmquist, A.



Materials, 10(2), 173.

Influence of Substrate Heating and Nitrogen Flow on the Composition, Morphological and Mechanical Properties of SiNx Coatings Aimed for Joint Replacements.

Skjöldebrand, C., Schmidt, S., Vuong, V., Pettersson, M., Grandfield, K., Högberg, H., Engqvist, H., Persson, C.



Nature Scientific Reports, 7, 39958.

Atomic scale chemical tomography of human bone.

Langelier, B., Wang, X., Grandfield, K.






ACS Biomaterials Science & Engineering, 3(1), 49-55.

3D characterization of human nano-osseointegration by on-axis electron tomography without the missing wedge.

Wang, X., Shah, F.A., Palmquist, A., Grandfield, K.



Surface and Coatings Technology, 296, 149-156.

Dual-topography electrical discharge machining of titanium to improve biocompatibility.

Lee, B.E.J., Ho, S., Mestres, G., Karlsson Ott, M., Koshy, P., Grandfield, K.



CrystEngComm, 18, 1064-1069.

Synthesis of calcium phosphate crystals with thin nacreous structure.

Chen, S., Grandfield, K., Shun, Y., Engqvist, H., Xia, W.



Archives of Oral Biology, 63, 82-92.

Effect of proteoglycans at interfaces as related to location, architecture, and mechanical cues.

Kurylo, M.P., Grandfield, K., Aloni, S., Altoe, V., Marshall, G.W., Young, M., Ho, SP.






RSC Advances,5 (121), 99848-99855.

Fabrication of translucent nanoceramics via a simple filtration method.

Cai, Y., Chen, S., Grandfield, K., Engqvist, H., Xia, W.



Annals of Biomedical Engineering, 1-13.

Surface and Subsurface Analyses of Metal-on-Polyethylene Total Hip Replacement Retrievals.

Vuong, V., Pettersson, M., Persson, C., Larsson, S., Grandfield, K., Engqvist, H.



Bone Reports, 3, 20-31.

Strain-guided mineralization in the bone-PDL-cementum complex of a rat periodontium.

Grandfield, K., Herber, R.P., Chen, L., Djomehri, S., Tam, T., Lee, J.H., Brown, E., Woolwine III, W.R., Curtis, D., Ryder, M., Schuck, P.J., Webb, S., Landis, W., Ho, S.P.



Physics Today, 68(4).

Bone, implants and their interfaces.

Grandfield, K.


*Invited feature article and cover article.


ACS Biomaterials Science and Engineering. 1(5), 305-313.

High-resolution visualisation of the osteocyte lacuno-canalicular network juxtaposed to the surface of nanotextured titanium implants in human.

Shah, F., Wang, X., Thomsen, P., Grandfield, K., Palmquist, A.






Journal of Materials Science and Technology, 31(2), 174-179.

Three-Dimensional Techniques for Evaluation of Osseointegrated Titanium Implants.

Thorfve, A., Palmquist, A., & Grandfield, K.


*Invited submission.


Nanoscale, 6(24):14991-8.

Atomic layer deposition-based tuning of the pore size in mesoporous thin films studied by in situ grazing incidence small angle x-ray scattering.

Dendooven, J., Devloo-Casier, K., Ide, M., Grandfield, K., Kurttepeli, M., Ludwig, K.F., Bals, S., Van Der Voort, P., and Detavernier, C.



Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, 228(8):754-67.

The narwhal (Monodon monoceros) cementum-dentin junction (CDJ): A functionally graded biointerphase.

Grandfield, K., Chattah, N.L., Djomehri, S., Eidelman, N., Eichmiller, F.C., Schuck, P.J., Nweeia, M.T., & Ho, S.P.



Biointerphases, 9, 029001.

Characterization of Dental Interfaces with Electron Tomography.

Grandfield, K., & Engqvist, H.


*Cover article.





Bone, 57(2):455-467.

The plastic nature of the human bone-periodontal ligament-tooth fibrous joint.

Ho SP, Kurylo MP, Grandfield K, Hurng J, Herber R-P, Ryder MI, Altoe V, Aloni S, Feng J, & Webb S.


*Cover article.


PLoS ONE, 8(7), e68486.

A Template-Free, Ultra-Adsorbing, High Surface Area Carbonate Nanostructure.

Forsgren, J., Frykstrand, S., Grandfield, K., Mihranyan, A., & Strømme, M.



Nanoscale, 5(10), 4302-4308.

Where bone meets implant: the characterization of nano-osseointegration.

Grandfield, K., Gustafsson, S., & Palmquist, A.



Journal of Biomaterials and Nanobiotechnology, 04(02), 107–113.

Effect of Calcium and Strontium on Mesoporous Titania Coatings for Implant Applications.

Grandfield, K., Pujari, S., Ott, M., Engqvist, H., & Xia, W.



Ultramicroscopy, 127, 48–52.

Three-dimensional structure of laser-modified Ti6Al4V and bone interface revealed with STEM tomography.

Grandfield, K., Palmquist, A., & Engqvist, H.






Philosophical Transactions of the Royal Society A-Mathematical Physical and Engineering Sciences, 370(1963), 1337–1351.

High-resolution three-dimensional probes of biomaterials and their interfaces.

Grandfield, K., Palmquist, A., & Engqvist, H.



Biomatter, 2(1), 15-23.

Resolving the CaP-bone interface: A review of discoveries with light and electron microscopy.

Grandfield, K., Palmquist, A., Engqvist, H., Thomsen, P.



Advances in Materials Science and Engineering, 2012, 1–6.

Focused Ion Beam in the Study of Biomaterials and Biological Matter.

Grandfield, K., & Engqvist, H.



Journal of Materials Science: Materials in Medicine, 23(8), 1879–1889.

Fabrication and evaluation of Si(x)N (y) coatings for total joint replacements.

Olofsson, J., Pettersson, M., Teuscher, N., Heilmann, A., Larsson, K., Grandfield, K., et al.



Journal of The Royal Society Interface, 9, 396–400.

Bone-titanium oxide interface in humans revealed by transmission electron microscopy and electron tomography.

Palmquist, A., Grandfield, K., Norlindh, B., Mattsson, T., Brånemark, R., & Thomsen, P.



Journal of Biomedical Materials Research Part B: Applied Biomaterials, 100(1), 82–93.

Mesoporous titanium dioxide coating for metallic implants.

Xia, W., Grandfield, K., Hoess, A., Ballo, A., Cai, Y., & Engqvist, H.



International Journal of Nano and Biomaterials, 4(1), 1–11.

Ultrastructural characterisation of the hydroxyapatite–coated pedicle screw and human bone interface.

Grandfield, K., Ericson, F., & Sandén, B.



Clinical Implant Dentistry and Related Research, 14(3), 461–469.

Bone Response to Free-Form Fabricated Hydroxyapatite and Zirconia Scaffolds: A Transmission Electron Microscopy Study in the Human Maxilla.

Grandfield, K., Palmquist, A., Ericson, F., Malmström, J., Emanuelsson, L., Slotte, C., et al.






Nanotechnology, 22(30), 305610.

Synthesis and release of trace elements from hollow and porous hydroxyapatite spheres.

Xia, W., Grandfield, K., Schwenke, A., & Engqvist, H.



Journal of Materials Science: Materials in Medicine, 22(4), 899–906.

Free form fabricated features on CoCr implants with and without hydroxyapatite coating in vivo: a comparative study of bone contact and bone growth induction.

Grandfield, K., Palmquist, A., Gonçalves, S., Taylor, A., Taylor, M., Emanuelsson, L., et al.






Journal of The Royal Society Interface, 7(51), 1497–1501.

Visualizing biointerfaces in three dimensions: electron tomography of the bone-hydroxyapatite interface.

Grandfield, K., McNally, E. A., Palmquist, A., Botton, G. A., Thomsen, P., & Engqvist, H.


*Cover article





Surface & Coatings Technology, 203(10-11), 1481–1487.

Electrophoretic deposition of polymer-carbon nanotube–hydroxyapatite composites.

Grandfield, K., Sun, F., FitzPatrick, M., Cheong, M., & Zhitomirsky, I.






Materials Characterization, 59(1), 61–67.

Electrophoretic deposition of composite hydroxyapatite–silica–chitosan coatings.

Grandfield, K., & Zhitomirsky, I.

















Multiscale Microscopy of Biomaterials

Grandfield Research Group | Dr. Kathryn Grandfield | Assistant Professor | Materials Science and Engineering School of Biomedical Engineering | McMaster University, ETB rm 403 | 1280 Main St W, Hamilton ON Canada L8S 4L7

Research funded by:

Multiscale Microscopy of Biomaterials